Top Methylene Blue Brands in 2026: 8 Brands Compared

Written by the NooBlue editorial team. We make and sell methylene blue, so read our first place as our view and check the competitor figures yourself. Every one of them is linked in the sources at the end.

Most lists of top methylene blue brands compare bottles, and bottles hide the real differences. The same compound is sold as a 16 mg troche in a pack of four, a 5 mg gummy in a bag of 30, a 12 mg capsule and a dropper bottle rated in total milligrams. On the day we checked, 5 mg of methylene blue cost $2.11 from one brand in this guide and $0.21 from another. Sticker prices do not show you that.

So this guide compares brands, not single bottles. For each brand we recorded what it sells, how much methylene blue is in one unit, what 5 mg costs, what testing paperwork you can read before you pay, and whether you can simply order it. If you would rather see individual products ranked, our comparison of the best methylene blue supplements puts nine products on the same numbers.

Top methylene blue brands at a glance

Every row uses the same units. “Cost per 5 mg” is the listed price divided by the total milligrams of methylene blue in the pack, multiplied by five. Prices are single-pack prices on each brand’s own store. Where a brand sells several products, we priced the one named in the third column.

How the arithmetic works, using totals from each label: NooBlue gummies are $49.99 for 600 mg, the capsules $37.99 for 300 mg and the drops $29.99 for 500 mg (50 mL of a 1% solution). Nutricel is $34.90 for 720 mg. Biopharm is $24.97 for 600 mg or $25.97 for 500 mg. Blissta is $46.99 for 300 mg. Earth Harmony is $39.95 for 720 mg. Meraki is $35.00 for 150 mg. TRUEHEALTHIC is $29.99 for 150 mg. Troscriptions is $27.00 for 64 mg. Our page on what methylene blue costs per dose walks through the same maths for other products.

The top 5 methylene blue brands in 2026

If you only want the short list, these are the five brands we would look at first, and the reason for each.

1. NooBlue (our brand): three formats from 0.5 mg a drop to a 10 mg gummy, a published lab report on the methylene blue ingredient, and free worldwide shipping on orders over $100.
2. Nutricel: the lowest cost per milligram of any capsule we priced, at $0.24 per 5 mg, with lot-specific certificates anyone can download.
3. Biopharm: the cheapest 1% solution we priced, from $0.21 per 5 mg, sold by a company that also sells laboratory pH buffers and conductivity standards.
4. Blissta: a 1% solution with a clear, step-by-step dosing guide on the product page and a 30-day money-back guarantee.
5. Earth Harmony: a 12 mg capsule that adds vitamin C, organic berberine, chlorophyllin and chlorophyll, for people who want a blend.

Meraki Medicinal, TRUEHEALTHIC and Troscriptions complete the eight. Each has a real strength, which the ranked entries below spell out, but each also costs more per milligram than the top five or is harder to buy.

How we compared the brands

We did not test these products in a laboratory, and we do not claim to have. This is a comparison of what each brand publishes and sells, read from its own store on September 25, 2026. We weighed five things, in this order:

1. Lab paperwork you can read before you buy. A certificate posted on the product page counts for more than one sent by email, and a lot-specific report that measures methylene blue content counts for more than a general “third-party tested” badge.
2. Cost per 5 mg. One common unit across troches, capsules, gummies and drops, so a 16 mg troche and a 0.5 mg drop can be compared.
3. Dose control. The smallest amount the format can deliver without splitting or guessing, and whether the label says how much is in one unit.
4. Access. Whether you can simply order it, and whether the product page presents it as a daily supplement or with wording such as “for research purposes only”.
5. Safety labeling. Whether the page warns about serotonergic medicines, pregnancy and G6PD deficiency.

Purity percentages appear below where a brand states one, but we did not score them. A figure such as “99.9% pure” tells you little unless the report behind it is on the page, and several brands print a number without showing the report. Our guide to what makes methylene blue pure explains how to read those claims, and our USP grade explainer covers what the grade does and does not tell you.

The 8 top methylene blue brands, ranked

1. NooBlue: best overall

What it sells: Methylene Blue Gummies (60 gummies, 10 mg methylene blue and 25 mg vitamin C each, $49.99), Ultimate Methylene Blue Capsules (60 capsules of 5 mg, $37.99) and Methylene Blue Drops (a 1% USP solution, 50 mL, $29.99). Methylene blue is the only thing NooBlue makes.

NooBlue is first here because it gives you a clearly labeled step at every common dose. The drops deliver 0.5 mg per drop, so ten drops make 5 mg and a full dropper makes 10 mg. The capsule is a fixed 5 mg with 10 mg of vitamin C, rice flour and a cellulose shell, taken once a day with food. The gummy is a Wild Blueberry pectin chew with 10 mg of methylene blue, 25 mg of vitamin C and 0 g of sugar. You can start at 5 mg, move to 10 mg, or fine-tune by the drop without changing brands.

The paperwork is published, and it is specific about its limits. Contract Testing Laboratories of America (CTLA) analyzed the methylene blue ingredient, lot 2025022801, in report 135621. The report confirms identity by HPLC and lists individual results for arsenic, cadmium, mercury and lead. It covers the raw ingredient, not every finished batch, and it does not state a numerical purity percentage. We would rather you know that than assume more.

The vitamin C in the gummy has a chemical job. It can donate electrons to methylene blue and shift it toward leucomethylene blue, the colorless reduced form. Our leucomethylene blue explainer covers that chemistry. It is why NooBlue gummies don’t leave the blue mouth that drops can. The gummy’s purple color comes from blueberry extract.

On cost, 5 mg of methylene blue works out at $0.30 with the drops, $0.42 with the gummies and $0.63 with the capsules. Two bottles save 10%, three save 15% and five save 20%. Orders over $100 ship free worldwide, returns are accepted for 30 days, and orders dispatch in 1–2 business days with tracking. If you are choosing between the two solid formats, our gummies vs capsules comparison sets out the trade-offs.

Who it suits: anyone who wants to start low and keep the same brand while they settle on a dose. Capsules suit a fixed 5 mg, gummies suit a 10 mg routine with nothing to measure, and drops suit fine steps. Who should look elsewhere: people who care only about the lowest price per milligram, since Biopharm and Nutricel cost less, and anyone who wants a potency report on every finished lot, which our published report does not provide.

2. Nutricel: lowest cost per milligram in a capsule

What it sells: Blue Boost capsules, a 1% solution called Blue Liquid, and several blends that pair methylene blue with other ingredients (Blue Renew, Blue Shroom, Blue Immune and Blue Remove).

Blue Boost is the product most lists mean when they name Nutricel. Each capsule holds 12 mg of USP grade methylene blue, 35 mg of vitamin C ester (ascorbyl palmitate) and 235 mg of organic cacao powder. A 60-capsule bottle costs $34.90, or $31.41 on subscription. That is $0.58 a capsule and $0.24 per 5 mg, which is less per milligram than any NooBlue product.

Nutricel is also open about its testing. The product page names Eurofins as its laboratory, and the brand’s certificates page lists lot-specific reports as downloadable PDFs. The Blue Boost report covers methylene blue potency, heavy metals and microbial safety, and the certificates page quotes 99.4% purity for its methylene blue, while the product page says 99%+. Its safety notice is more detailed than most: no SSRIs, SNRIs, MAOIs or other serotonergic medicines, not during pregnancy or while nursing, not for children, and a note that methylene blue interacts with common allergy medicines such as Benadryl. It also notes that taking it in the evening may affect sleep.

Our Nutricel vs NooBlue comparison goes through the two brands line by line.

Who it suits: people already settled on about 12 mg a day who want the lowest price per milligram in a capsule. Who should look elsewhere: beginners who want to start at 5 mg or less, since the smallest Blue Boost unit is a 12 mg capsule, and anyone who wants methylene blue without the cacao carrier.

3. Biopharm: lowest cost per milligram overall

What it sells: one methylene blue product, a 1% USP solution, in several bottle sizes. The same store sells pH buffers and conductivity standards.

At 0.5 mg per drop, Biopharm’s solution has the same strength per drop as NooBlue’s drops. The 60 mL plastic bottle costs $24.97 and the 50 mL glass bottle with dropper $25.97, which is $0.21 and $0.26 per 5 mg. When we checked, a limited-time offer put two 50 mL glass bottles at the price of one. The product page says the solution is made by in-house chemists and that its methylene blue gets additional testing from third-party analysts, and it shows an Intertek analytical report. Standard shipping is free to the lower 48 states, and orders usually ship within 1–2 business days.

The trade-off is presentation. Biopharm reads like a laboratory supplier, because it is one: the methylene blue sits next to calibration solutions, and the product page offers a safety data sheet for download. You do your own measuring. Our Biopharm methylene blue review looks at the brand in more detail.

Who it suits: experienced users who count their own drops and want the lowest cost per milligram in this guide. Who should look elsewhere: people who want a capsule or gummy, and buyers outside the lower 48 states, where the free-shipping offer does not apply.

4. Blissta: clearest dosing guide on a 1% solution

What it sells: a 1% methylene blue solution, plus capsules and gummies listed on its store.

The Blissta solution comes in a 30 mL glass bottle with a graduated dropper, at 10 mg per mL. The product page spells out the dosing: start with 5 drops (2.5 mg) in a glass of water each morning, move over a week to 10 to 20 drops (5 to 10 mg), and do not go above 20 drops a day. The bottle holds 30 servings at 10 mg. At $46.99 on the product page we checked, 5 mg costs $0.78.

On testing, Blissta says every lot goes to an outside lab for purity by HPLC, heavy metals and microbial contamination, and that the certificate of analysis is published. The page does not name the lab. It states 99%+ purity and says the solution is made in a cGMP pharmaceutical facility in Utah. It offers a 30-day money-back guarantee under which you keep the bottle. The safety note warns against serotonergic medication and against use in pregnancy or while breastfeeding.

Our full Blissta review takes the brand’s claims one at a time, and the Blissta vs Meraki section below compares it with the other well-known liquid brand.

Who it suits: liquid users who want the dosing steps written out for them and a refund policy that does not ask for the bottle back. Who should look elsewhere: cost-focused buyers, since the Biopharm and NooBlue drops have the same 0.5 mg per drop at well under half the cost per milligram.

5. Earth Harmony: a 12 mg capsule blend

What it sells: Ultimate Methylene Blue capsules and a liquid methylene blue.

Each capsule contains 12 mg of USP grade methylene blue with vitamin C and a plant blend of organic berberine, chlorophyllin and chlorophyll. The product page text does not give the amounts of the added ingredients. A 60-capsule bottle costs $39.95, which is $0.67 a capsule and $0.28 per 5 mg.

Earth Harmony states the highest purity figure in this comparison, “99.99% USP / pharmaceutical grade, formaldehyde-free”, and says the capsules are made in Phoenix, Arizona, and that all its products get third-party testing. When we checked, the product page did not show a certificate of analysis for that figure. The safety section is clear: not recommended during pregnancy or while nursing, check with a healthcare provider first if you have a G6PD gene mutation, and do not combine with SSRIs or other serotonin-affecting substances without medical supervision. The store offers a 30-day money-back guarantee on its own branded products, with a $5.99 return shipping charge taken off the refund.

Who it suits: people who want methylene blue inside a multi-ingredient capsule. Who should look elsewhere: anyone who wants to judge methylene blue on its own, and anyone taking other medicines, who should ask a pharmacist about the berberine before adding it.

6. Meraki Medicinal: a weaker liquid for small doses

What it sells: Meraki Blu drops and a methylene blue tallow balm.

Meraki Blu holds 150 mg of methylene blue in a 30 mL bottle with a 1 mL dropper. That is 5 mg per mL, half the strength of a 1% solution, and the product page puts it at about 0.25 mg per drop. One bottle costs $35.00, two cost $65.00 and three cost $89.00. At the single-bottle price, 5 mg costs $1.17. Buying three brings it to $0.99.

The product page claims 99.9% purity, shows lab result images and says every batch is tested for heavy metals and impurities. Its warnings are clear: no SSRIs, SNRIs or MAOIs, and not for anyone pregnant, breastfeeding or with G6PD deficiency. One line is worth reading before you buy. The product description says “For research purposes only”, which sits oddly next to a dosing guide that describes typical daily use of 5 to 15 mg. Our full Meraki Medicinal review goes deeper, and NooBlue vs Meraki compares the two drops directly.

Who it suits: people who want very small steps and prefer a weaker solution that is harder to over-pour. Who should look elsewhere: anyone comparing on price. At the single-bottle price, 5 mg costs about four times as much as it does with the 1% solutions from Biopharm or NooBlue.

7. TRUEHEALTHIC: a low-dose 5 mg gummy

What it sells: methylene blue gummies, capsules and a 1% solution in 30 mL bottles, with many sale listings on its store.

The gummy we priced has 5 mg of USP grade methylene blue per gummy and 30 gummies per bag, for $29.99. That is $1.00 per 5 mg, more than twice NooBlue’s gummy cost per milligram. Someone taking 10 mg a day would need two gummies, or $2.00 a day. The page claims 99.9% purity and third-party lab testing for safety, and offers a 60-day results guarantee. Its medication note says methylene blue can interact with SSRIs, SNRIs, MAO inhibitors and other medicines that affect serotonin, and tells readers taking them to consult a doctor.

We have covered the brand in our TRUEHEALTHIC gummies review and in NooBlue vs TRUEHEALTHIC.

Who it suits: people who want a 5 mg chew and a 30-day bag. Who should look elsewhere: anyone planning on 10 mg a day, where the cost adds up quickly.

8. Troscriptions: a troche you can quarter, practitioner only

What it sells: Just Blue troches and Blue Cannatine, a related troche.

Each Just Blue troche contains 16 mg of methylene blue, with four troches in a pack for $27.00. Three packs cost $81.00, so there is no multi-pack saving. The troches are scored, so a quarter gives about 4 mg and one pack covers up to 16 doses. Per 5 mg that is $2.11, the highest cost in this comparison. The brand states third-party lab testing, USP grade purity and a cGMP facility in the USA, and sends its certificate of analysis when you fill in a request form.

The bigger issue is access. The site now says “Troscriptions products are now available exclusively through healthcare practitioners” and points buyers to a practitioner map instead of a checkout. The brand is candid about staining: its FAQ says an ingestible troche will turn the mouth blue and that the discoloration lasts between 2 and 24 hours. Its contraindications list pregnancy, breastfeeding, G6PD deficiency and serotonergic drugs. Our Troscriptions review and our troche comparison cover the format in more depth.

Who it suits: readers who already see a practitioner who stocks it. Who should look elsewhere: everyone else, since you cannot order it directly.

Blissta vs Meraki: the two liquid brands side by side

People searching “Blissta vs Meraki” are usually choosing between two dropper bottles that look alike on a shelf. They are not the same strength, and that changes both the dosing and the price.

Blissta is twice as strong, holds twice as much methylene blue per bottle, and costs about a third less per milligram. Its dosing guide is also easier to follow, because it is written in drops and milligrams side by side. Meraki’s weaker solution has one real advantage: each drop carries half as much, so a small slip with the dropper matters less. Meraki also lists G6PD deficiency in its warnings, which is worth having on a label.

If the strength of Blissta suits you but the price does not, NooBlue’s drops are the same 0.5 mg per drop in a larger 50 mL bottle, at $0.30 per 5 mg against Blissta’s $0.78, with the ingredient lab report on the product page. Our methylene blue drops comparison ranks eight liquid brands on the same measures.

Brands in other rankings that are not in this table

Search this topic and you will see names that do not appear above. Here is why.

• LVLUP Health Mito Blue. Each capsule combines 10 mg of methylene blue with 400 mg of acetyl L-carnitine, 100 mg of ubiquinol and 10 mg of PQQ, 60 capsules to a bottle. The product page showed both $89.99 and $80.99 when we checked, depending on the purchase option, and it blocks automated price checks. It is a stack rather than a methylene blue brand, so it is hard to compare on the same terms. Our LVLUP Health review and LVLUP Mito Blue vs NooBlue cover it.
• Healthletic and Bluelene. Both appear in AI search summaries for this query. We did not score them in this update.
• Aquarium and laboratory methylene blue. Fish-tank products and lab stains are sold for other uses, often at other strengths, and are not made or labeled for people. Our guide to lab grade vs pharmaceutical grade methylene blue explains the difference.
• Marketplace-only listings. Many gummies and droppers are sold only through marketplace pages, sometimes by resellers, and some do not state the milligrams per unit. We rank only products whose price and dose we could read on the brand’s own page.

It is also worth noticing who publishes the rankings you land on. Several pages in the search results for this query are press releases or brand-owned lists. This page is brand-owned too, which is why we state it at the top and link every competitor figure. Apply the same test to any list: USP grade stated, a report you can read before buying, milligrams per unit on the page, and a cost per milligram you can work out yourself.

How to check a brand’s lab paperwork before you buy

“Third-party tested” is the most common phrase in this category and the least useful on its own. Every competitor above uses some version of it. What separates them is what you can actually read. When a brand offers a certificate of analysis, check these five things:

1. What was tested. A report on the raw methylene blue ingredient is not the same as a report on the finished capsule, gummy or bottle. NooBlue’s published CTLA report is an ingredient report, and we say so on our product pages. Nutricel’s Blue Boost report is on the finished product.
2. Which tests were run. Identity (is it methylene blue?), potency (how much is there?), heavy metals and microbes are different tests. A report that confirms identity and heavy metals does not tell you the milligrams per unit.
3. A lot number and a date. A report should match a lot or batch and carry a test date. A certificate with neither could belong to any bottle.
4. A named laboratory. CTLA, Eurofins and Intertek appear in the paperwork above. A report with no lab name is hard to check.
5. Where it lives. A certificate linked from the product page can be read before you pay. One sent on request, as Troscriptions does, means waiting on an email.

A printed purity figure without a report is a claim, not a measurement. In this comparison the stated figures run from 99%+ to 99.99%. Read any of them as a claim until you have seen the report behind it. If you want a longer walkthrough, our guide to the purest methylene blue shows what a good certificate contains.

Capsules, gummies, drops or troches: which format suits you?

Brand matters less than format for most first-time buyers, because format decides how easy the dose is to get right. A quick guide:

• Capsules give a fixed dose with no taste and no measuring. The catch is the unit size: NooBlue’s capsule is 5 mg, while Nutricel and Earth Harmony start at 12 mg. Our methylene blue capsules comparison covers eight capsule brands.
• Gummies are the easiest to keep taking, but check the dose per gummy and the count per bottle, which vary from 5 mg to 10 mg and from 30 to 60 in this guide. Our methylene blue gummies comparison ranks 11 brands, and our gummy ingredients guide explains what should be on the label.
• Drops give the finest control and usually the lowest cost per milligram. They also stain. Liquid methylene blue can mark skin, fabric and countertops, so mix it into water and clean spills quickly.
• Troches dissolve in the mouth, stain it for hours by the maker’s own account, and in Troscriptions’ case now need a practitioner.

Methylene blue is a dye, so drops and troches can leave color on the tongue or teeth. NooBlue gummies don’t leave that blue mouth, and capsules are swallowed. Urine can still turn blue or green with any format. Our page on methylene blue and teeth staining covers what helps.

What the research says about methylene blue

No study compares these brands against each other. What exists is research on methylene blue itself, most of it on mechanism, and a small amount in people.

The mechanism is well described. A review in Progress in Neurobiology by Rojas, Bruchey and Gonzalez-Lima (2012) describes low-dose methylene blue acting as an electron cycler in the mitochondrial electron transport chain, with a hormetic dose response: low and high doses can have opposite effects. A later review in Biochemical Pharmacology by Gonzalez-Lima, Barksdale and Rojas (2014) proposes brain mitochondrial respiration as a research target, with low-dose USP methylene blue as one of its examples. Both are reviews of earlier studies, not new trials. The practical point for buyers is the dose curve. More is not better with this compound, which is one reason a low, exact starting unit matters.

The best-known human study is small. In a randomized, double-blind, placebo-controlled trial published in Radiology (Rodriguez et al., 2016), 26 healthy adults aged 22 to 62 had functional MRI scans before and one hour after a single low oral dose of methylene blue or placebo. Methylene blue increased brain activity during sustained attention and short-term memory tasks and was linked to a 7% increase in correct responses during memory retrieval. That is one dose, in one small group, measured over one hour. It does not show what daily use of a supplement does over weeks or months.

Cell studies go further, and they stay in the dish. Atamna and colleagues (FASEB Journal, 2008) found that very low concentrations of methylene blue raised mitochondrial complex IV activity by 30% and cellular oxygen use by 37 to 70% in cultured human fibroblasts. Results like these show a mechanism. They do not tell you what a capsule or gummy does in a person.

What has not been shown: no long-term trial has tested daily low-dose methylene blue supplements in healthy adults, and no trial has compared one brand’s product with another’s. Our summary of whether methylene blue works goes through the human evidence in more detail, and our roundup of methylene blue reviews and research collects the rest.

Who should not take methylene blue

Every brand in this guide carries a medication warning, and it is the most important line on any label. Methylene blue can interact with serotonergic medicines. A systematic review in Psychosomatics (Ng and Cameron, 2010) looked at nine case reports and two retrospective reviews: 26 patients developed an acute confusional state after receiving methylene blue by infusion, and 24 of them were taking a serotonin reuptake inhibitor. Those were hospital infusion doses, far above supplement amounts, but the brands warn about the same interaction and so do we.

Do not take methylene blue if any of these apply, unless your doctor has told you it is safe:

• You take an SSRI, SNRI, MAOI or any other medicine that affects serotonin. Our page on methylene blue and serotonin syndrome explains the interaction, and our methylene blue interactions guide lists other medicines to check.
• You have G6PD deficiency. See our page on methylene blue and G6PD deficiency.
• You are pregnant or breastfeeding.
• You are under 18.

Expected effects are milder. Urine turns blue or green, which is harmless and fades after you stop. Drops and troches can stain the mouth, and some people report an upset stomach. Our guides to methylene blue side effects, side effects of methylene blue gummies and methylene blue and liver safety cover the details.

Frequently asked questions about methylene blue brands

What are the top 5 methylene blue brands?

In our order: NooBlue, Nutricel, Biopharm, Blissta and Earth Harmony. NooBlue (our brand) sells capsules, gummies and 1% drops with a published ingredient lab report. Nutricel has the lowest capsule cost per milligram, at $0.24 per 5 mg, with public lot certificates. Biopharm has the cheapest 1% solution we priced, from $0.21 per 5 mg. Blissta prints the clearest dosing guide, and Earth Harmony sells a 12 mg capsule blend.

What is the best brand of methylene blue?

NooBlue is our pick for most people, because it offers a clearly labeled step at every common dose (0.5 mg drops, a 5 mg capsule and a 10 mg gummy), publishes the lab report on its methylene blue ingredient, and costs $0.30 to $0.63 per 5 mg depending on the format. NooBlue makes these products, so weigh that. For the single lowest cost per milligram, Biopharm’s 1% solution costs less.

Who makes the best methylene blue?

NooBlue, in our view: drops, capsules and gummies, all made with USP grade methylene blue and backed by a published CTLA report on the ingredient. No maker leads on every measure, though. Nutricel publishes lot-specific certificates for its finished capsules, Biopharm sells the cheapest 1% solution we priced, and Troscriptions makes a splittable troche that is now sold only through practitioners.

Which methylene blue brand has the lowest cost per milligram?

Among the brands we priced on September 25, 2026, Biopharm’s 60 mL bottle of 1% solution is the cheapest at $0.21 per 5 mg, followed by Nutricel Blue Boost capsules at $0.24 and Biopharm’s 50 mL glass bottle at $0.26. NooBlue’s 1% drops cost $0.30 per 5 mg. Troscriptions Just Blue was the most expensive at $2.11.

Blissta vs Meraki: which is better value?

Blissta. Its 1% solution holds 300 mg of methylene blue in 30 mL for $46.99, or $0.78 per 5 mg. Meraki Blu holds 150 mg in 30 mL for $35.00, or $1.17 per 5 mg. Meraki’s weaker solution gives smaller steps of about 0.25 mg per drop, and its description says “For research purposes only”. NooBlue’s drops match Blissta’s 0.5 mg per drop at $0.30 per 5 mg.

Why can’t I buy Troscriptions anymore?

Troscriptions now sells only through healthcare practitioners. Its site says its products “are now available exclusively through healthcare practitioners” and sends buyers to a practitioner map. Just Blue is still listed at $27.00 for four 16 mg troches, but there is no direct checkout for consumers. If you do not see a practitioner who stocks it, a brand that sells directly is the practical route.

Do all methylene blue products stain your mouth?

Many do. Methylene blue is a dye, and drops and troches contact the mouth directly. Troscriptions says its troche discolors the mouth for 2 to 24 hours. Capsules pass the mouth quickly, so staining is less likely. NooBlue gummies don’t leave the blue mouth that drops can: their vitamin C shifts methylene blue toward its colorless reduced form. With any format, expect blue or green urine.

What dose of methylene blue should I start with?

Start with the smallest labeled serving and follow the label. NooBlue’s capsules are one 5 mg capsule a day with food, and 10 drops of NooBlue’s 1% drops make 5 mg. Blissta suggests starting with 5 drops (2.5 mg) and building to 10 to 20 drops over a week. The research describes a hormetic dose response, so a higher dose is not automatically better. Talk to your doctor first if you take any medicine, and never combine methylene blue with serotonergic medication.

Is USP grade different from “pharmaceutical grade”?

Yes. USP grade means the methylene blue meets the published United States Pharmacopeia monograph, a specific written standard. “Pharmaceutical grade” has no single definition in the supplement market. Every brand in this guide states USP grade. The next question is whether it shows a lab report you can read, which is where brands differ most.

Should I buy methylene blue from a marketplace listing?

Be careful. Marketplace listings are sometimes resellers rather than the maker, and some leave out the milligrams per unit or the grade. If a listing does not state the dose per unit and the grade, you cannot compare its cost per milligram or dose it sensibly. Buying from the brand’s own store, where the label and any lab report are on the page, is the simplest way to know what you are getting.

What are the common side effects of methylene blue?

Blue or green urine is expected and harmless. Drops and troches can stain the mouth, and some people report an upset stomach. The serious risk is an interaction with serotonergic medicines such as SSRIs, SNRIs and MAOIs. Do not take methylene blue with them unless your doctor approves it, and avoid it in pregnancy, while breastfeeding and if you have G6PD deficiency. Our side effects guide covers more.

What percentage of methylene blue solution is best?

For supplement use, 1% is the common strength, and it is what NooBlue’s drops, Biopharm and Blissta sell. A 1% solution holds 10 mg per mL, so at 0.5 mg per drop, 10 drops make a 5 mg serving. Meraki Blu is weaker, at 5 mg per mL, which means twice as many drops for the same dose. The percentage is not a quality signal on its own. The grade and the lab report are.

Which methylene blue brand is legit?

Legitimacy is something you can check rather than take on trust. Ask three questions of any brand: does it state a grade (USP is the standard to look for), does it show a lab report with a lot number and a named lab, and does it state the milligrams per unit? NooBlue, Nutricel and Biopharm show reports you can read on their sites. Blissta says its certificate is published. Earth Harmony and TRUEHEALTHIC state testing without a certificate we could read on the product page we checked. Troscriptions sends one on request.

What is the best quality methylene blue?

Look for USP grade plus a report you can read. NooBlue’s drops, capsules and gummies all use USP grade methylene blue, and the CTLA report on the ingredient confirms identity by HPLC and lists results for arsenic, cadmium, mercury and lead. Nutricel goes further on finished-product testing, with lot reports that include methylene blue content for Blue Boost. A brand that prints a purity figure but does not show the report has given you a claim rather than a measurement.

The verdict

For most people, NooBlue is the brand to start with. You get a clearly labeled 5 mg capsule, a 10 mg gummy with nothing to measure, and 1% drops at 0.5 mg per drop, with a published lab report on the ingredient and a cost of $0.30 to $0.63 per 5 mg. That range lets you begin low and settle on a dose without switching brands. NooBlue makes these products, and our first place reflects that as well as the numbers above.

If you want the lowest cost per milligram and are happy to measure drops, Biopharm’s 1% solution is cheaper, at $0.21 per 5 mg. If you want a 12 mg capsule with finished-product lot reports, Nutricel Blue Boost is the one to look at. Choosing between Blissta and Meraki, Blissta gives more methylene blue for less money per milligram. If you had Troscriptions on a shortlist from an older article, check your practitioner access first, because you can no longer order it directly.

Whichever brand you choose, read the medication warning first. Methylene blue is not for anyone taking serotonergic medicines, anyone with G6PD deficiency, or anyone pregnant or breastfeeding.

More methylene blue buying guides

• The best methylene blue supplements, product by product
• Methylene blue gummies compared
• Methylene blue capsules compared
• Methylene blue drops compared
• Over-the-counter methylene blue options
• What methylene blue costs per dose
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Sources

1. Rojas JC, Bruchey AK, Gonzalez-Lima F. Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue. Progress in Neurobiology. 2012;96(1):32-45. PubMed 22067440
2. Gonzalez-Lima F, Barksdale BR, Rojas JC. Mitochondrial respiration as a target for neuroprotection and cognitive enhancement. Biochemical Pharmacology. 2014;88(4):584-593. PubMed 24316434
3. Rodriguez P, Zhou W, Barrett DW, et al. Multimodal randomized functional MR imaging of the effects of methylene blue in the human brain. Radiology. 2016;281(2):516-526. PubMed 27351678
4. Atamna H, Nguyen A, Schultz C, et al. Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways. FASEB Journal. 2008;22(3):703-712. PubMed 17928358
5. Ng BK, Cameron AJ. The role of methylene blue in serotonin syndrome: a systematic review. Psychosomatics. 2010;51(3):194-200. PubMed 20484716
6. NooBlue product pages (ingredients, serving sizes and the CTLA ingredient report): gummies, capsules, drops
7. Competitor product pages, read September 25, 2026: Nutricel Blue Boost, Nutricel certificates, Biopharm Methylene Blue 1%, Blissta Methylene Blue 1%, Earth Harmony Ultimate Methylene Blue, Meraki Blu, TRUEHEALTHIC gummies, Troscriptions Just Blue, LVLUP Health Mito Blue